Investigators say at least two suspects shot Butler and a woman while they were driving on Ivy and Lorena Avenues around 1:30 a.m.
Officers received a ShotSpotter call of 18 rounds and later found the victims' car in the middle of the roadway.
Investigators found a car in the middle of the roadway with a man and woman inside suffering from gunshot wounds.
Emergency crews performed CPR on Butler and rushed him to Community Regional Medical Center. He died about an hour later.
Officials say the woman was also hospitalized but is expected to survive. Her name has not been released.
Witnesses say several people appeared out of nowhere and fired upon the two victims.
"Unfortunately, because of the darkness, the witnesses we have contacted were not able to provide much more than a description of describing them as males," said Fresno Police Lt. Bill Dooley.
Two apartments at a nearby complex were hit by gunfire, shattering a glass door and another apartment where a mother and child were inside.
No one else was injured.
A motive for the shooting has not been released, but detectives say Butler was targeted.
Anyone with information is asked to call the Fresno Police Department.
This is a developing story. Stay with us for updates.