Lowrie homered and moved over 1,000 hits for his career, and the Oakland Athletics held on for an 8-7 victory over the Los Angeles Angels on Sunday, their ninth win in 11 games.
Lowrie took no issue with a potential blowout turning into a nail-biter, a rare occurrence for Oakland's bullpen.
"Who cares?" Lowrie said. "We won."
The A's took the series against the Angels by winning the last two games. Oakland, which currently occupies the second AL wild-card spot, moved within 2 1/2 games of first-place Houston in the AL West. The Astros have lost four straight.
Oakland is now 36-12 over its last 48 games, the second-best record in baseball over that stretch, behind the Boston Red Sox. The A's have taken 13 of their past 16 series.
Angels manager Mike Scioscia went with a bullpen day, but the strategy backfired when reliever Taylor Cole (0-3), making his first career start, allowed three runs on three hits in 1 1/3 innings.
"It becomes more of a Who's fresh?' game than a matchup game with the bullpen," Scioscia said. "You try to do your best to put guys in good spots, but right now we're not there. We're looking at whoever's available to give us innings. We try to line 'em up as best we can, but we're not as efficient as it is if you have the functionality of having starters get to a certain point in the game, which right now we just don't have."
Lowrie doubled to left field in Oakland's three-run first inning, giving him 1,000 hits over 11 seasons. It was also the 250th double of his career. Lowrie's 1001st career hit was his 18th homer this season, a two-run shot during a four-run fourth for the A's.
"It was a lot of hard work that has gone into (1,000 hits)," said Lowrie, who took a grounder off his hand early in Sunday's game and has spent the last month recovering from a bone bruise in his left leg. "It's one of those big round numbers that is exciting and memorable, so it's a pretty special moment."
Marcus Semien had three hits for the A's and reached base four times, a day after hitting a pair of home runs. Lowrie also had a walk as he reached base three times.
Los Angeles trailed by as many as four but pulled within a run in the eighth inning on Shohei Ohtani's two-run single off Jeurys Familia. Blake Treinen struck out the side in the ninth for his 30th save in 34 opportunities. A's pitchers matched a season high with 16 strikeouts.
Rookie Francisco Arcia homered for the Angels. The homer, his third, came one day after Arcia pitched a scoreless mop-up inning. Justin Upton had two hits for the Angels, including an eighth-inning double that gave him an extra-base hit in five consecutive games.
A's starter Trevor Cahill allowed four runs on seven hits with a walk over 4 2/3 innings.
"I think it was the first game this year when I didn't have my changeup, which has been kind of my go-to and my savoir, especially if the fastball command isn't there," Cahill said.
Fernando Rodney (4-2) pitched a scoreless inning in relief to earn his first victory for the A's. Rodney has two scoreless innings with Oakland after being acquired from the Minnesota Twins on Thursday.
"Today is a day when you need a guy like him," A's manager Bob Melvin said. "We feel like we have a deep 'pen, but on days like this is when you need an extended bullpen with that kind of depth."
OHTANI ON TRACK
Scioscia reiterated Sunday that he expects Ohtani to pitch again this season. While the two-way rookie from Japan has returned to designated-hitter duties, he has not pitched since June 6 because of a sprained right elbow ligament.
Ohtani will have what will amount to a medium-intensity bullpen session Monday in San Diego, where the Angels will open a three-game series. He would then work higher-intensity bullpens, followed by pitching to hitters, before his return.
Scioscia would not specify when he expects Ohtani to pitch again, but the likelihood is mid-to-late September.
"The goal is pitching again this year and we feel that is attainable," Scioscia said.
Angels: LHP Tyler Skaggs (left adductor strain) returned to the 10-day disabled list following his rough outing Saturday, when he gave up seven runs on 10 hits over 3 1/3 innings against the A's. ... SS Andrelton Simmons was a late scratch from the lineup with left knee soreness and is day-to-day. ... C Rene Rivera (arthroscopic knee surgery) was expected to play in a game at Single-A Inland Empire on Sunday and Monday, with the Angels hoping he can return to the active roster during the upcoming road trip to San Diego, Texas and Arizona.
A's: LHP Sean Manaea (10-8, 3.50 ERA) will take the mound Monday at home against the Seattle Mariners, having lasted just 2 2/3 innings in a start against the Los Angeles Dodgers last week.
Angels: LHP Andrew Heaney (7-7, 3.96 ERA) will start Monday at San Diego, his first career appearance against the Padres.
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Ohtani plates two to bring Angels within one
Shohei Ohtani takes Jeurys Familia the other way, hitting a single to left-center field and scores two runs in the 8th inning.