49ers' Isaac Guerendo set to play; Dre Greenlaw activated

San Francisco 49ers running back Isaac Guerendo is active on Thursday night against the Los Angeles Rams despite his sprained foot.

Guerendo, who was listed as questionable, insists he "feels good," sources had told ESPN's Adam Schefter earlier Thursday.

The 49ers activated linebackerDre Greenlaw off the PUP list Thursday for his first game back from a torn Achilles suffered during last season's Super Bowl.

Niners defensive end Nick Bosa (left hip, oblique) is also active after missing the past three games.

The 49ers (6-7) likely need to win to get back in the playoff hunt. They ruled out left tackle Trent Williams (left ankle), safety Malik Mustapha (chest, shoulder) and guard Ben Bartch (high ankle sprain) on Wednesday. Bartch was placed on injured reserve Thursday.

Guerendo assumed the starting running back job following injuries to Christian McCaffrey, Elijah Mitchell and Jordan Mason. He rushed for 78 yards and two touchdowns and chipped in two receptions for 50 yards Sunday against the Chicago Bears before exiting with his foot injury.

The rookie running back did not practice Monday or Tuesday but was upgraded to limited in Wednesday's walk-through.

If Guerendo were limited, Patrick Taylor Jr.would be next in line for work out of the backfield with practice squad back Ke'Shawn Vaughn and recently added Israel Abanikanda also available as options.

Before departing against the Bears, Guerendo etched himself into the 49ers record books with his successful first start. He became the fourth player in franchise history to have 100-plus scrimmage yards and at least two touchdowns in his first start, joining Carlos Hyde (2015), Earl Cooper (1980) and Hugh McElhenny (1952).

Information from ESPN's Nick Wagoner was used in this report.br/]