FRESNO, California (KFSN) -- Fisher was hired in 2012 and amassed a record of 31-45-1 in nearly five seasons.
"Making a decision such as this - especially during the season - is one of the most difficult in sports," said Rams Owner/Chairman E. Stanley Kroenke. "I have great respect for Jeff as a coach, person, father and friend.
"He has worked tirelessly despite some challenging circumstances. He played an integral role in helping this team make history in returning the NFL to Los Angeles, and we always will be grateful for his commitment and dedication to our organization.
"However, this is the right time to make a change as our performance has not lived up to my or our fans' expectations. We all are focused on improving as an organization and building a team that makes Los Angeles proud. Our mission is to celebrate a Super Bowl title with our fans in Los Angeles. Today is the first step to bringing us closer to that goal."