About 700 firefighters were battling the so-called Blue Cut Fire, which began Tuesday morning as a small brush fire near Devore and quickly developed into conflagration.
Driven by dry brush and gusty conditions, the blaze led Gov. Jerry Brown to issue a state of emergency in the county. The proclamation provides more state resources to firefighting efforts and grants certain benefits to affected residents, such as waiver of fees for destroyed documents and faster unemployment benefits.
MORE: Full list of evacuations, road closures, animal shelters and school information
Among the areas under mandatory evacuation orders were the community of Wrightwood, Lone Pine Canyon, Phelan, Lytle Creek Canyon and West Oak Hills. The evacuation area includes some 34,500 homes.
It was unclear how many structures have been destroyed by the inferno.
Early Wednesday morning, the California Highway Patrol announced the closure of eastbound California 138 at California 18, and eastbound Californa 2 at Big Pines Highway.
Those shutdowns came amid the several ongoing closures, including two sections of Interstate 15: northbound from Interstate 215 at Kenwood Avenue, as well as the southbound 15 from Ranchero Road to the 215.
The cause of the fire was unknown.