Los Angeles Chargers LT Rashawn Slater (torn biceps) out for season, LB Joey Bosa (groin) week-to...

COSTA MESA, Calif. -- Left tackle Rashawn Slater and edge rusher Joey Bosa are among theLos Angeles Chargers players who suffered significant injuries in a lopsided Week 3 loss to the Jacksonville Jaguars.

Slater will miss the remainder of the season after tearing his left biceps tendon and Bosa will be sidelined indefinitely because of a groin injury, according to coach Brandon Staley.

"It's going to be a tough loss for us," Staley said about Slater, the Bolts' 13th overall pick in 2021 who earned Pro Bowl recognition as a rookie last season. "We're going to make sure over the next couple of days that we put good contingency plans in place."

Staley said he was uncertain if Bosa would be placed on injured reserve. "He'll probably be week-to-week," Staley said. Wide receiver Jalen Guyton also will be sidelined for the remainder of the season after suffering a torn ACL late in the fourth quarter. He was placed on IR on Tuesday.

"It's a tough one, he was playing a good game," Staley said of Guyton, a fourth-year pro who in a reserve role had two catches for 64 yards.

Storm Norton, who lost a training camp competition with Trey Pipkins III for the right tackle job, took over at left tackle when Slater left the game in the third quarter. Veteran linebacker Kyle Van Noy and edge rusher Chris Rumph II took over for Bosa.

With the 38-10 loss to the Jaguars, the Chargers fell to 1-2, and now prepare for back-to-back road games at Houston and Cleveland.

Staley expressed confidence that despite losing multiple key players, several other starters who have been dealing with injury issues, including quarterback Justin Herbert,were holding steady, if not improving.

"Not setbacks at the game," Staley said of Herbert, who completed 25 of 45 passes for 297 yards and a touchdown, with an interception and lost sack fumble, while playing through fractured rib cartilage suffered 10 days earlier.

A day removed from leaving Herbert in the game late in the fourth quarter, down 20 points, Staley would not go so far as to say he regretted leaving the Pro Bowl quarterback in the game, but indicated that moving forward, a different decision would be made.

"It definitely was my decision to keep him out there," Staley said, adding later, "If I had to do it again or if I have to do it again, I need to make sure that I communicate to Justin [that] in a tough circumstance like that when you're behind, that you've already done enough. I look forward to that next time, but in that moment, I don't regret how we went through that together."

Herbert told reporters after the game he remained in the game because he "just didn't want to quit on the team."

Staley said that Pro Bowl center Corey Linsley, who was inactive Sunday because of a knee issue, was improving and expressed optimism that he would return to practice, along with receiver Keenan Allen, who has been sidelined the last two games because of a hamstring injury.

And Staley provided some clarification in regard to the situation surrounding cornerback J.C. Jackson, their marquee offseason free agent acquisition. Jackson underwent ankle surgery last month and was sidelined for the season opener, but played 100% of the snaps in Week 2 before he was inactive again Sunday.

Staley said Jackson had "inflammation" inside his ankle, but that there was "nothing structural."

"Just making sure that he doesn't go out there and have something else happen," Staley said. "There was just some inflammation that we were taking a look at and again, just being cautious looking at the long term."