The 21-year-old victim who later died from the wounds drove through a fence and stopped on an adjacent road, French said.
They were both transported to a local hospital where the man died.
The woman told police she did not know the suspects or why they shot at them, French said. She is expected to survive.
The suspects were only described as two black men driving a full-sized, red van.
The eastbound side of the highway from Regatta Boulevard to Bayview Avenue was closed for about an hour, according to the California Highway Patrol.
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