The fire broke out around 9 p.m. Wednesday night at the mobile home park at Linden and Highway 33 in Gustine.
Cal Fire officials say when fire fighters arrived the single-wide mobile was fully engulfed. They were able to contain the flames to one home.
Authorities have not released the names of the victims, but they do believe they were an elderly couple.
So far, investigators don't know what caused the fire.