The U.S. Geological Survey said that over the next two hours quakes with magnitudes of 3.5, 3.0, and 3.6 rumbled in the same area.
Another temblor with a preliminary magnitude of 3.4 was recorded shortly after 5:30 a.m.
Sheriff's dispatcher Steve Davis said the quake-hit zone is sparsely populated.
"There's really not a lot out there," he said. "Nobody has felt a thing so far."
On Thursday, the USGS reported that a 3.5 magnitude quake hit at 4:10 a.m. and was followed within 90 minutes by three others measuring 3.2, 3.2 and 3.4.
Those temblors were centered 6 miles southeast of Coso Junction in Inyo County and about 18 miles north of Ridgecrest in Kern County.
That area of the upper Mojave Desert has been hit by dozens of tiny earthquakes in the past two weeks but none have caused any problems.
