It was the 25th time NASA has brought a space shuttle back to Earth in darkness - representing just one-fifth of all missions.
Endeavour left the International Space Station over the weekend. The astronauts put the finishing touches on the orbiting lab, installing a $2 billion cosmic ray detector, an extension beam and a platform full of spare parts - enough to keep the station operating in the shuttle-less decade ahead.
Endeavour will have traveled 123 million miles by flight's end and spent 299 days in space and circled Earth more than 4,600 times. It's the youngest of NASA's shuttles, first flying in 1992 as the replacement for Challenger.
Endeavor's next and final stop will be at the Los Angeles California Science Center.
The Associated Press contributed to this story