Police initially received reports of a speeding driver, traveling 100 mph, heading eastbound in the westbound lanes of La Palma Avenue around 7 p.m.
The driver later ran a red light and a hit a woman who was walking in the area. The car then crossed into the opposite lanes and hit at least six vehicles.
The female victim was pronounced dead at a local hospital.
The wrong-way driver was also transported, his or her condition remains unknown. Investigators were working to determine whether alcohol played a role in the incident.