The 46-year-old is starring in a new one-man show, "Ghetto Klown." The autobiographical production debuts Feb. 21 at the Lyceum Theater and officially opens March 22 and runs 12 weeks.
"Ghetto Klown" will follow the early days of Leguizamo's acting career as well as his roles in Hollywood. It will follow in the tradition of his shows "Spic-O-Rama," "Freak" and "Sexaholix."
Leguizamo's new show will be directed by Fisher Stevens.
Leguizamo won an Emmy for his monologue "Freak," which originally appeared on Broadway in 1998.
He was nominated for a Golden Globe Award for his supporting role in 1995's "To Wong Foo Thanks for Everything, Julie Newmar."
The Associated Press contributed to this report.