Caltrans has shut down all but one lane of Northbound 99 between Jensen and Ashlan in Fresno for a re-paving project.
Both eastbound and westbound Highway 180 connectors to Highway 99 will also be closed.
Caltrans says drivers can expect the ramps onto 99 to be closed temporarily along the nine mile construction area.
The closures begin at 7:00 Thursday night and will last until 6:00 Friday morning.