It happened around seven last night on Highway 140 near Owens Creek Road.
That's near the Merced-Mariposa County line.
The CHP says a Mitsubishi truck was speeding on the highway when it crossed the double yellow line on a curve and crashed into an oncoming Chevrolet truck.
Both people in the Mitsubishi were killed.
One person in the Chevrolet has serious leg injuries and was taken to a Modesto hospital. The driver had minor injuries.
It's not clear yet if alcohol or drugs played a role in the crash.