Hayley Munro's jumper early in the second half brought the bulldogs to within three, but they would get no closer as the Brittney Griner show started.
Griner went on a personal 6-0 run to blow the game open. Emma Andrews' three-pointer made it an 11-point game with less than six minutes left.
But Baylor was just too much. Kelli Griffin had a career-high 11 assists.
69-55 is the final score.
With the loss, the bulldogs see their season end at 27 and 7 on the year. While the lady bears move on to play Georgetown in the second round.