Fresno police say the crash happened at Herndon and Blackstone.
Officers found the motorcyclist lying on the roadway.
He was later identified as 21-year-old Noah Ruiz Hernandez of Fresno.
Investigators say Hernandez crashed into a truck near the intersection and was thrown from the bike.
The driver of the truck stayed on scene and cooperated with officers.
Drugs or alcohol do not appear to have been factors in this crash.
The intersection of Blackstone and Herndon was shut down for several hours.