Just after 2 am, officers found 24-year-old Jacob Sales with multiple gunshot wounds on Mayor Avenue between Inyo and Mono, across from Frank H. Ball Park.
He was rushed to Community Regional Medical Center, where he died.
Investigators say Sales was standing outside of his home when two men confronted him, and one of them opened fire.
The suspects ran away from the area before officers arrived.
Detectives are now asking anyone with information to contact the Fresno Police Department.
This is Fresno's 17th homicide of the year.